| Player | Team | Comp | Pass Yds | Pass TD | Int | Ru Yds | Ru TD |
|---|
| Patrick Mahomes | KC | 26.0 | 316.4 | 2.4 | 0.7 | 19.6 | 0.2 |
| Joe Burrow | CIN | 24.8 | 280.9 | 2.0 | 0.8 | 14.3 | 0.2 |
| Trevor Lawrence | JAC | 24.4 | 272.0 | 1.7 | 0.7 | 19.2 | 0.2 |
| Josh Allen | BUF | 22.0 | 256.1 | 1.9 | 0.9 | 42.7 | 0.4 |
| Jared Goff | DET | 22.0 | 255.6 | 1.6 | 0.7 | 5.1 | 0.1 |
| Aaron Rodgers | GB | 22.4 | 247.6 | 1.9 | 0.6 | 6.1 | 0.1 |
| Geno Smith | SEA | 22.1 | 246.6 | 1.8 | 0.8 | 16.6 | 0.1 |
| Dak Prescott | DAL | 21.9 | 244.3 | 1.9 | 0.8 | 15.0 | 0.1 |
| Jalen Hurts | PHI | 19.7 | 240.6 | 1.6 | 0.6 | 47.0 | 0.6 |
| Joe Flacco | NYJ | 21.5 | 234.0 | 1.2 | 0.8 | 2.5 | 0.0 |
| Kirk Cousins | MIN | 19.0 | 230.6 | 1.6 | 0.6 | 5.2 | 0.1 |
| Jarrett Stidham | DEN | 20.6 | 226.2 | 1.4 | 1.0 | 13.8 | 0.1 |
| Justin Herbert | LAC | 22.0 | 226.1 | 1.5 | 0.7 | 11.4 | 0.1 |
| Russell Wilson | DEN | 20.2 | 226.0 | 1.2 | 0.8 | 21.1 | 0.2 |
| Brock Purdy | SF | 19.1 | 222.1 | 1.8 | 0.7 | 6.8 | 0.1 |
| Baker Mayfield | TB | 19.5 | 213.1 | 1.2 | 0.9 | 8.2 | 0.1 |
| Mac Jones | NE | 19.9 | 208.7 | 1.1 | 0.8 | 9.2 | 0.1 |
| Andy Dalton | CAR | 18.0 | 208.6 | 1.4 | 0.7 | 5.0 | 0.1 |
| Kenny Pickett | PIT | 19.8 | 207.9 | 1.1 | 0.8 | 18.6 | 0.2 |
| Deshaun Watson | CLE | 17.7 | 204.3 | 1.2 | 0.7 | 27.9 | 0.2 |
| Davis Mills | HOU | 18.0 | 199.0 | 1.0 | 0.8 | 8.9 | 0.1 |
| Sam Ehlinger | IND | 19.1 | 198.8 | 1.1 | 0.9 | 20.5 | 0.1 |
| Sam Howell | WAS | 18.2 | 197.2 | 1.0 | 1.0 | 18.6 | 0.1 |
| Skylar Thompson | MIA | 18.4 | 196.6 | 1.1 | 1.0 | 8.4 | 0.1 |
| Sam Darnold | CAR | 16.4 | 195.3 | 1.1 | 0.7 | 14.9 | 0.2 |
| David Blough | ARI | 18.5 | 192.7 | 0.8 | 1.0 | 7.6 | 0.0 |
| Joshua Dobbs | TEN | 16.2 | 184.5 | 0.9 | 0.9 | 14.8 | 0.1 |
| Davis Webb | NYG | 17.5 | 184.0 | 0.9 | 1.0 | 8.8 | 0.1 |
| Desmond Ridder | ATL | 16.1 | 175.6 | 1.1 | 0.7 | 21.3 | 0.2 |
| Nathan Peterman | CHI | 15.1 | 164.0 | 0.9 | 1.1 | 9.2 | 0.0 |
| Tom Brady | TB | 12.6 | 155.8 | 1.0 | 0.4 | 1.1 | 0.0 |
| Anthony Brown | BAL | 10.5 | 125.0 | 0.6 | 0.6 | 21.0 | 0.1 |
| Daniel Jones | NYG | 4.7 | 107.1 | 0.6 | 0.4 | 23.2 | 0.1 |
| Blaine Gabbert | TB | 10.7 | 101.9 | 0.5 | 0.3 | 3.3 | 0.0 |
| Chase Daniel | LAC | 4.9 | 46.7 | 0.3 | 0.1 | 1.5 | 0.0 |
| Nick Mullens | MIN | 5.3 | 45.7 | 0.3 | 0.1 | 1.6 | 0.0 |
| Tyrod Taylor | NYG | 5.3 | 34.4 | 0.2 | 0.1 | 3.6 | 0.0 |
| Kyle Trask | TB | 2.6 | 29.5 | 0.1 | 0.1 | 1.1 | 0.0 |
| Jeff Driskel | HOU | 2.2 | 23.7 | 0.1 | 0.1 | 14.8 | 0.1 |
| Teddy Bridgewater | MIA | 0.6 | 18.2 | 0.1 | 0.1 | 0.4 | 0.0 |
| Zach Wilson | NYJ | 0.3 | 13.4 | 0.1 | 0.0 | 0.3 | 0.0 |
| Jameis Winston | NO | 0.4 | 11.5 | 0.1 | 0.0 | 0.3 | 0.0 |
| Gardner Minshew | PHI | 0.9 | 10.6 | 0.1 | 0.0 | 0.5 | 0.0 |
| Matt Ryan | FA | 0.5 | 10.5 | 0.1 | 0.1 | 0.5 | 0.0 |
| Bailey Zappe | NE | 0.4 | 9.6 | 0.0 | 0.1 | 0.1 | 0.0 |
| Jacoby Brissett | CLE | 0.3 | 8.9 | 0.0 | 0.0 | 0.4 | 0.0 |
| Taylor Heinicke | ATL | 0.4 | 7.8 | 0.0 | 0.1 | 0.5 | 0.0 |
| Brandon Allen | CIN | 0.4 | 7.7 | 0.0 | 0.0 | 0.2 | 0.0 |
| Josh Johnson | SF | 0.3 | 7.7 | 0.1 | 0.0 | 0.5 | 0.0 |
| Mitchell Trubisky | PIT | 0.4 | 7.5 | 0.1 | 0.1 | 0.4 | 0.0 |
| C.J. Beathard | JAC | 0.3 | 7.0 | 0.1 | 0.0 | 0.1 | 0.0 |
| Jordan Love | GB | 0.4 | 6.8 | 0.0 | 0.0 | 0.3 | 0.0 |
| P.J. Walker | CAR | 0.3 | 6.5 | 0.0 | 0.0 | 0.5 | 0.0 |
| Chad Henne | KC | 0.6 | 5.1 | 0.0 | 0.0 | 0.1 | 0.0 |
| Cooper Rush | DAL | 0.5 | 4.4 | 0.0 | 0.0 | 0.3 | 0.0 |
| Drew Lock | SEA | 0.5 | 4.1 | 0.0 | 0.0 | 0.4 | 0.0 |
| Case Keenum | HOU | 0.5 | 4.0 | 0.0 | 0.0 | 0.3 | 0.0 |
| Brett Rypien | DEN | 0.5 | 3.9 | 0.0 | 0.0 | 0.4 | 0.0 |
| Tim Boyle | CHI | 0.4 | 3.6 | 0.0 | 0.1 | 0.2 | 0.0 |
| Trace McSorley | ARI | 0.5 | 3.4 | 0.0 | 0.0 | 0.4 | 0.0 |
| Bryce Perkins | LAR | 0.4 | 3.3 | 0.0 | 0.0 | 0.4 | 0.0 |
| Malik Willis | TEN | 0.4 | 2.8 | 0.0 | 0.0 | 0.6 | 0.0 |
| Nate Sudfeld | DET | 0.4 | 2.4 | 0.0 | 0.0 | 0.1 | 0.0 |
| Logan Woodside | ATL | 0.2 | 2.3 | 0.0 | 0.0 | 0.2 | 0.0 |
| Chase Garbers | LV | 0.0 | 0.4 | 0.0 | 0.0 | 0.1 | 0.0 |
| Brian Hoyer | NE | 0.0 | 0.3 | 0.0 | 0.0 | 0.0 | 0.0 |
| Marcus Mariota | ATL | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Matthew Stafford | LAR | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Trevor Siemian | CHI | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Mike Glennon | MIA | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Brett Hundley | BAL | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Ryan Tannehill | TEN | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Kyler Murray | ARI | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |